Keytruda (pembrolizumab) vs Zynyz (retifanlimab-dlwr)

Keytruda (pembrolizumab) vs Zynyz (retifanlimab-dlwr)

Keytruda (pembrolizumab) and Zynlonta (loncastuximab tesirine-lpyl, not Zynyz) are both monoclonal antibodies used in cancer treatment, but they target different proteins and are used for different types of cancer. Keytruda targets the PD-1 receptor and is widely used for various cancers, including melanoma, lung cancer, and head and neck cancer, among others. Zynlonta, on the other hand, is an antibody-drug conjugate that targets CD19 and is used for the treatment of certain types of B-cell lymphomas. It is important for patients to consult with their healthcare provider to determine the most appropriate treatment based on their specific type and stage of cancer, as well as their overall health status.

Difference between Keytruda and Zynyz

Metric Keytruda (pembrolizumab) Zynyz (retifanlimab-dlwr)
Generic name Pembrolizumab Retifanlimab-dlwr
Indications Various types of cancers including melanoma, lung cancer, head and neck cancer, Hodgkin lymphoma, and others Advanced or metastatic solid tumors with high microsatellite instability or mismatch repair deficiency
Mechanism of action Programmed death receptor-1 (PD-1) blocking antibody Programmed death receptor-1 (PD-1) blocking antibody
Brand names Keytruda Zynyz
Administrative route Intravenous infusion Intravenous infusion
Side effects Fatigue, musculoskeletal pain, decreased appetite, pruritus, diarrhea, nausea, rash, fever, cough, dyspnea, constipation, pain in extremity, and headache Similar to pembrolizumab, with potential for infusion-related reactions, fatigue, musculoskeletal pain, and others
Contraindications Severe hypersensitivity to pembrolizumab or any of its excipients Severe hypersensitivity to retifanlimab or any of its excipients
Drug class Anti-PD-1 monoclonal antibody Anti-PD-1 monoclonal antibody
Manufacturer Merck & Co. Incysus Therapeutics, Inc.

Efficacy

Efficacy of Keytruda (Pembrolizumab) in Treating Skin Cancer

Keytruda, also known by its generic name pembrolizumab, is a highly effective immunotherapy drug used in the treatment of various types of cancer, including skin cancer. It is particularly used for advanced stages of melanoma, a dangerous form of skin cancer. Pembrolizumab is a type of monoclonal antibody that works by blocking the PD-1 pathway, which cancer cells often exploit to hide from the immune system. By inhibiting this pathway, Keytruda enables the immune system to better recognize and destroy cancer cells.

Clinical trials have demonstrated that Keytruda significantly improves survival rates in patients with advanced melanoma. In some studies, pembrolizumab has shown a considerable increase in progression-free survival and overall survival compared to other treatments. Its efficacy has been observed both in patients who have not received prior treatment and in those who have progressed after other therapies. As a result, Keytruda has become a standard of care for advanced melanoma and has received approval from various regulatory agencies for this indication.

Efficacy of Zynyz (Retifanlimab-dlwr) in Treating Skin Cancer

Zynyz, with the generic name retifanlimab-dlwr, is a relatively new player in the field of immunotherapy for cancer treatment. As of the knowledge cutoff date in 2023, Zynyz is not specifically approved for the treatment of skin cancer. It is an anti-PD-1 therapy, similar to pembrolizumab, and is designed to help the immune system recognize and fight cancer cells. While it may hold potential for treating various types of cancer, including skin cancer, its efficacy in this particular area would be subject to the outcomes of clinical trials and research studies.

Since retifanlimab-dlwr is under investigation, any data on its efficacy for skin cancer would come from clinical trials that are either ongoing or completed. It is important for patients and healthcare providers to consult the latest research and clinical trial results to understand the potential benefits and risks of Zynyz in the context of skin cancer. As with any investigational drug, the efficacy and safety profile of retifanlimab-dlwr will be better understood once more data from these trials become available and regulatory authorities evaluate it for specific indications.

Regulatory Agency Approvals

Keytruda
  • European Medical Agency (EMA), European Union
  • Food and Drug Administration (FDA), USA
  • Health Canada
  • Therapeutic Goods Administration (TGA), Australia
  • Medsafe (NZ)
Zynyz
  • Food and Drug Administration (FDA), USA

Access Keytruda or Zynyz today

If Keytruda or Zynyz are not approved or available in your country (e.g. due to supply issues), you can access them via Everyone.org.

How it works

Make an enquiry

Choose the medicine you want to buy, answer a couple of questions, and upload your prescription to speed things up. We’ll get back to you within 24 hours.

Breeze through the paperwork

We'll guide you through the required documents for importing unapproved medicine, ensuring you have all the necessary information.

Get a personalized quote

We’ll prepare a quote for you, including medicine costs and any shipping, administrative, or import fees that may apply.

Receive your medicine

Accept the quote and we’ll handle the rest - sourcing and safely delivering your medicine.

Some text on this page has been automatically generated. Speak to your physician before you start a new treatment or medication.

Let's talk

If you have any questions, call us or send us a message through WhatsApp or email:

Contact us
US 0